Objective: We performed a systematic review and meta-analysis of published demiological studies of developmental fluo-. ride neurotoxicity. Developmental Fluoride Neurotoxicity: Choi et al. Respond . fluoride neurotoxicity: a systematic review and meta-. analysis. Environ Health. “Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis” is a study published in Environmental Health.

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Citations Publications citing this reivew. This study is a systematic review and meta-analysis of 27 previously published studies. To investigate the effect of increased fluoride exposure on delayed neurobehavioral development sywtematic children. In total, we identified 27 eligible epidemiological studies with high and reference exposures, end points of IQ scores, or related cognitive function measures with means and variances for the two exposure groups.

Chin Prim Health Care. Neurotoxicity of sodium fluoride in rats. Results of the review Twenty-seven studies were included in the meta-analysis with sample sizes that ranged from 60 to children. OBJECTIVE We performed a systematic review and meta-analysis of published studies to investigate the effects of increased fluoride exposure and delayed neurobehavioral development.

Neurotoxicity Syndromes Fluorides Confidence Intervals. Policy flhoride Institutional Considerations. Another study Trivedi et al. Two of the studies included in the analysis were conducted in Iran Poureslami et al.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis

Systematic Reviews in Health Care: Although microbiologically safe, water supplies from small springs or mountain sources created pockets of increased exposures near or within areas of low exposures, thus representing exposure settings close to the ideal, because only the fluoride exposure would differ between nearby neighborhoods.

However, as research on other neurotoxicants has shown, a shift to the left of IQ distributions in a population will have substantial impacts, especially among those in the high and low ranges of the IQ distribution Bellinger Four studies published in English Li XS et al. The effect of age and year of publication devwlopmental investigated using meta-regression. Please review our privacy policy. High fluoride and low iodine environment and subclinical cretinism in Xinjiang.


Studies were combined in suitable meta-analyses. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.

Severe dental fluorosis and cognitive deficits. Neurottoxicity Inf Prev Med. However, results of the published studies have not been widely disseminated. The mean IQ of children in the high-fluoride area was significantly lower than that from the reference fluoride area.

Developmental fluoride neurotoxicity: a systematic review and meta-analysis.

We searched records for — A recent cross-sectional study based on individual-level measure of exposures suggested that low levels of water fluoride range, 0. Estimates of effect were converted into standardised mean differences SMD and pooled in Mantel-Haenszel fixed-effect and DerSimonian-Laird random-effects meta-analyses. In response to the recommendation of the NRCthe U. Average IQ scores were significantly lower in high-fluoride group and -iodine than the reference group.

Inclusion criteria and data extraction. As with anything, the dose makes the poison.

Each critical abstract contains a brief summary of the review methods, results and conclusions followed by a detailed critical assessment on the reliability of the review and the conclusions drawn. The latter showed that dose-related deficits were found, but the studies were excluded because our meta-analysis focused on studies with the high- and low-exposure groups only. Methods of synthesis Estimates of effect were converted into standardised mean differences SMD and pooled in Mantel-Haenszel fixed-effect and DerSimonian-Laird random-effects meta-analyses.


A preliminary exploration of IQ of 7—13 year old pupils in a fluorosis area with contamination from burning coal. Publication of EHP lies in the public domain and is therefore without copyright. Footnotes This study was supported by internal institutional funds.

Developmental fluoride neurotoxicity: a systematic review and meta-analysis.

We conducted sensitivity analyses restricted to studies using the same outcome assessment and having drinking-water fluoride as the only exposure. Showing of 76 extracted citations. Second revision of Chinese-Binet Intelligence Test. Open in a separate window. Retrieved March 20, Children in the high-fluoride low-iodine area had lower IQ scores compared with systejatic children from the reference fluoride low-iodine areas.

A standardized weighted mean difference SMD was computed using both fixed-effects and random-effects models. Inthe Ministry of Health reported that fluorosis was found in 28 provinces with 92 million residents China News Topics Discussed in This Paper.

Future research should include detailed individual-level information on prenatal exposure, neurobehavioral wystematic, and covariates for adjustment. Skip to search form Skip to main content.

Average IQ of children in high-fluorosis area was lower than that in the reference area. The study has been repeatedly cited by anti-fluoridation groups which include bastions of science like Joseph Mercola and NaturalNews as slam-dunk evidence. Quantifying heterogeneity in a meta-analysis. Support Center Support Center. Bio Trace Elem Res.

Exclude nonstandardized testsa 23 —0. The authors call for future research to include more precise data on the children involved and greater confidence that other factors have been ruled out as contributing to differences in IQ test scores.